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Graphene Oxide Catalyzed One‐pot Synthesis of Pyrimido[4,5‐b]quinolinone‐2,4‐diones and their Biological Evaluation
Author(s) -
Singha Rabindranath,
Basak Puja,
Bhattacharya Malay,
Ghosh Pranab
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000989
Subject(s) - catalysis , quinoline , oxide , chemistry , barbituric acid , graphene , molar ratio , aryl , reaction conditions , antimicrobial , organic chemistry , combinatorial chemistry , materials science , nanotechnology , alkyl
A simple and highly efficient method for the synthesis of 5‐aryl‐pyrimido quinoline 2,4‐diones has been demonstrated. Graphene oxide (GO) has proved to be a new class of carbocatalyst for the synthesis of pyrimido[4,5‐b]quinolinone‐2,4‐diones through one‐pot three component reaction using aromatic amines, aldehydes, and barbituric acid. The antimicrobial activity of the synthesized compounds was examined for the first time. The effects e. g. reaction temperature, catalyst amount, reaction time, the molar ratio of reactants were investigated. The GO could easily be recovered and reused upto 5 th run without loss of its catalytic activity.