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Oxidative Amidation of Aldehydes with Amines Catalysed by Fe(II) – Hydride Complex and N‐ Heterocyclic Carbenes (NHC)
Author(s) -
Singh Ashmita,
Azad Chandra S.,
Narula Anudeep K.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000981
Subject(s) - carbene , chemistry , catalysis , hydrogen peroxide , hydride , oxidative phosphorylation , toluene , oxidative addition , ligand (biochemistry) , medicinal chemistry , organic chemistry , combinatorial chemistry , hydrogen , biochemistry , receptor
Oxidative amidation reaction of aldehydes with amines, by tert butyl hydrogen peroxide in toluene was achieved. The reaction utilised the in situ generated catalyst produced by Fe(II) – hydride complex [FeH 2 (PPh 3 ) 4 ], and N‐heterocyclic carbene (NHC) ligand. The catalytic system was found efficient for the synthesis of wide variety of mono and disubstiuted amides.