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Fluorescent pH‐Responsive Mesoporous Silica Nanoparticles with Core‐Shell Feature as a Traceable Delivery Carrier for Ibuprofen
Author(s) -
Wei Tingting,
Sheng Mengdi,
Liu Chang,
Sun Jihong,
Wu Xia,
Bai Shiyang
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000934
Subject(s) - mesoporous silica , fluorescence , materials science , nanoparticle , chemical engineering , mesoporous material , acrylic acid , drug delivery , drug carrier , chemistry , nanotechnology , copolymer , organic chemistry , composite material , catalysis , polymer , optics , physics , engineering
The fluorescent pH‐responsive mesoporous silica nanoparticles (P@BMMs) were prepared, in which, the (2‐[3‐(triethoxysilyl) propyl]‐1H‐Benz [de]isoquinoline‐1, 3(2H)‐dione) ‐ poly(acrylic acid) (PID‐PAA) shell was covalently anchored onto the vinyl‐modified surface of the bimodal mesoporous materials (BMMs) core via one‐step or two‐step process. Their structural features were analyzed by XRD, SEM, TEM, TG, and SAXS, and the results showed that P@BMMs possessed typical fractal features from structural irregularity to surface roughness. Ibuprofen as a model drug was loaded into the mesopore channels of BMMs cores, particularly, the drug‐releasing performances from P@BMMs carriers were pH‐dependent. Meanwhile, the photoluminescent emission spectra and the fluorescent decay profiles presented that the hybrid P@BMMs with strong fluorescent intensity at 395 nm and 450 nm and longer decay lifetimes (such as 3.53 and 18.86 ns for P@BMMs‐I‐10) is a promising drug carrier, which can be used in potential applications for controlled drug delivery.