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In Vitro Antioxidant and Insulin Mimetic Activities of Heteroleptic Oxovanadium(IV) Complexes with Thiosemicarbazones and Naproxen
Author(s) -
Bharathi Sundaram,
Mahendiran Dharmasivam,
Senthil Kumar Raju,
Kalilur Rahiman Aziz
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000911
Subject(s) - naproxen , chemistry , in vitro , antioxidant , electron paramagnetic resonance , redox , insulin , nuclear chemistry , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , nuclear magnetic resonance , pathology , medicine , physics , alternative medicine , endocrinology
Six heteroleptic oxovanadium(IV) complexes with general formula [VOL 1–6 (nap)], where, L 1–3 =2‐(1‐(4‐substitutedphenyl)ethylidene)hydrazinecarbothioamide, L 4–6 =2‐(1‐(4‐substitutedphenyl)ethylidene)‐ N ‐methylhydrazinecarbothioamide and nap=naproxen, have been synthesized and characterized. FTIR spectra exhibit a strong band between 965 and 991 cm −1 , characteristic of υ(V=O) stretching vibration. UV‐Vis and theoretical studies suggested distorted square‐pyramidal geometry and oxidation state of vanadium(IV) with d 1 configuration was confirmed by EPR spectra. Cyclic voltammograms exhibit metal based irreversible redox peaks corresponding to one electron oxidation (+0.83 to +0.70 V) and reduction (−0.69 to −0.53 V) processes. In vitro antioxidant studies revealed that complexes containing electron donating substituent (−CH 3 ) showed higher activity. In vitro antidiabetic activity of complexes with enzymes like α‐amylase, α‐glucosidase and glucose‐6‐phosphatase made them better inhibitors of insulin, which is further supported by in silico studies, and complex 6 shows better in vitro insulin mimic activity against insulin responsive 3T3‐L1 adipocyte cells compared to insulin and metformin.