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Green Analysis of the Bromination Reaction of Propiophenone Derivatives Mediated by Cu 2+ Complexes
Author(s) -
Krapacher Claudio R.,
Rossi. Laura I.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000899
Subject(s) - halogenation , propiophenone , chemoselectivity , regioselectivity , chemistry , medicinal chemistry , bromide , organic chemistry , catalysis , ketone
All processes and reactions were evaluated using green metrics. Alternatives for the α‐halogenation reaction of ketones were studied, varying both the methodology and the brominating reactants. CuBr 2 and its complexes with organic ligands derived from biomass were used as bromide source. Distinct regioselectivity and chemoselectivity were observed with the different complexes used. The CuBr 2 ‐βCD complex behave completely different to the rest of the complexes since the halogenation occurred preferentially in the propiophenone aromatic ring. Among the complexes used, novel starch and chitosan complexes with CuBr 2 were synthesized and characterized by EPR, FT‐IR, UVV RD and TGA.