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Ultrasensitive Fluorescent Detection of Tetracycline Based on Selective Supramolecular Interaction of Nitrogen Chlorine Co–Doped Graphene Quantum Dots
Author(s) -
Gu Bingli,
Chen Da,
Gao Bo,
Liu Zhiduo,
Wang Zihao,
Wang Ting,
Yang Yongsheng,
Guo Qinglei,
Wang Gang
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000816
Subject(s) - fluorescence , quantum yield , quantum dot , graphene , detection limit , chlorine , photochemistry , materials science , citric acid , chemistry , tetracycline , analytical chemistry (journal) , nanotechnology , nuclear chemistry , inorganic chemistry , organic chemistry , chromatography , optics , biochemistry , physics , antibiotics
Herein, a simple bottom‐up method for producing nitrogen and chlorine co‐doped graphene quantum dots (N, Cl‐GQDs) was proposed by utilizing citric acid and 3,4‐dichloroaniline via hydrothermal treatment, and a fluorescent sensor for the detection of tetracycline was demonstrated. These synthesized N, Cl‐GQDs consist mostly of 1–3 layers with a uniform size of about 4.5 nm. Strong blue fluorescence with a quantum yield of 23.2 % was observed from the obtained N, Cl‐GQDs when irradiated with a 365 nm UV light. Systematic studies indicate that N, Cl‐GQDs have several superior features, including excitation‐independent emission, high monodispersity, good stability and water solubility. Moreover, the fluorescence intensity of N, Cl‐GQDs could be significantly quenched by the addition of a small amount of tetracycline. Finally, a fluorescent probe for the detection of tetracycline with a detection limit of 68 nM was proved, which exhibits great potentials for biosensors and biological imaging.