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Synthesis of Novel Furo[3,2‐c]coumarin Derivatives through Multicomponent [4+1] Cycloaddition Reaction Using ZnO/FAp as a Sustainable Catalyst
Author(s) -
Kerru Nagaraju,
Lalitha Gummidi Ms.,
Kumar Gangu Kranthi,
Maddila Suresh,
Jonnalagadda Sreekantha B.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000796
Subject(s) - catalysis , aldehyde , chemistry , cycloaddition , condensation reaction , coumarin , zinc , carbon 13 nmr , solvent , atom economy , nuclear chemistry , organic chemistry
An efficient green protocol is developed for the synthesis of ten new furo[3,2‐c]coumarin derivatives employing zinc oxide loaded on fluorapatite (ZnO/FAp) as catalyst. The three‐component one‐pot condensation occurs between the 4‐hydroxycoumarin, isocyanide and selected aldehyde in ethanol solvent at room temperature. Excellent yields (94‐98 %) of target products in 16‐20 min reaction time is the attractive feature. As‐synthesized catalysts and organic compounds were fully established by powder‐XRD, TEM, SEM, EDX, FT‐IR, BET, HRMS, 1 H NMR and 13 C NMR analysis. The catalyst is recyclable up to five times with high efficacy and marginal loss of activity. The reaction facilitated 98 % of the atom economy and 100 % carbon efficiency. Other advantages of the protocol are mild reaction conditions, easy‐workup, green solvent, catalyst reusability, and chromatography free products.