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Design, Synthesis, and In vitro Evaluation of Thieno[a]dibenzothiophene Derivatives
Author(s) -
Konus Metin,
Algso Muheb A. S.,
Kavak Emrah,
KurtKızıldoğan Aslıhan,
Yılmaz Can,
Kivrak Arif
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000685
Subject(s) - dibenzothiophene , candida albicans , antimicrobial , electrophile , antifungal , chemistry , combinatorial chemistry , staphylococcus aureus , in vitro , stereochemistry , bacteria , organic chemistry , biology , microbiology and biotechnology , biochemistry , sulfur , genetics , catalysis
A variety of highly substituted thieno[2,3‐a]dibenzothiophenes and thieno[3,2‐ a ]dibenzothiophenes are readily prepared via cascade electrophilic cyclization reaction. The reaction was tolerated a variety of compounds. In the present study, antimicrobial and antifungal activities were investigated for all synthesized molecules against A. niger ATCC 16404, C. albicans ATCC 10231, S. aureus ATCC 25923 and B. subtilis ATCC 6633, respectively.