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Base‐Promoted Intramolecular Cyclization and Hydrolysis of 2‐(2‐Formylaryloxy)acetonitriles: An Efficient Domino to Approach Benzofuran‐2‐carboxamides
Author(s) -
A XueJiao,
Li Xia,
Liu Bo,
Huang GuoLi
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000650
Subject(s) - benzofuran , acetonitriles , intramolecular force , tandem , chemistry , combinatorial chemistry , hydrolysis , cascade reaction , indole test , yield (engineering) , stereochemistry , organic chemistry , catalysis , materials science , acetonitrile , metallurgy , composite material
A novel, efficient, and practical approach for the synthesis of benzofuran‐2‐carboxamides has been developed through the base‐promoted tandem intramolecular cyclization and hydrolysis of 2‐formylaryloxyacetonitriles at room temperature. This method provides a convenient route to benzofuran‐2‐carboxamides in up to 98% yield with favorable functional group compatibility. A gram‐scale reaction was also performed to demonstrate the scaled‐up applicability of this methodology.