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Kinetic Resolution of Racemic 2‐Aryloxy Propionyl Chlorides Using Enantiopure ( S )‐3,4‐Dihydro‐3‐methyl‐2 H ‐[1,4]benzoxazines
Author(s) -
Vakarov Sergey A.,
Chulakov Evgeny N.,
Sadretdinova Liliya Sh.,
Kodess Mikhail I.,
Ezhikova Marina A.,
Pervova Marina G.,
Ganebnykh Ilya N.,
Levit Galina L.,
Krasnov Victor P.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000629
Subject(s) - enantiopure drug , kinetic resolution , enantiomer , chemistry , stereoselectivity , resolution (logic) , stereochemistry , organic chemistry , catalysis , enantioselective synthesis , computer science , artificial intelligence
Abstract Stereoselectivity in the mutual kinetic resolution (KR) of racemic 3,4‐dihydro‐3‐methyl‐2 H ‐[1,4]benzoxazines and racemic 2‐aryloxy propionyl chlorides was studied. Based on the results obtained, preparative methods for single enantiomers of a series of 2‐aryloxy propionic acids via acylative KR of their racemates with enantiopure ( S )‐3,4‐dihydro‐3‐methyl‐2 H ‐[1,4]benzoxazines have been proposed.