Kinetic Resolution of Racemic 2‐Aryloxy Propionyl Chlorides Using Enantiopure ( S )‐3,4‐Dihydro‐3‐methyl‐2 H ‐[1,4]benzoxazines | Zendy

Vakarov Sergey A. | Zendy; Chulakov Evgeny N. | Zendy; Sadretdinova Liliya Sh. | Zendy; Kodess Mikhail I. | Zendy; Ezhikova Marina A. | Zendy; Pervova Marina G. | Zendy; Ganebnykh Ilya N. | Zendy; Levit Galina L. | Zendy; Krasnov Victor P. | Zendy

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Kinetic Resolution of Racemic 2‐Aryloxy Propionyl Chlorides Using Enantiopure ( S )‐3,4‐Dihydro‐3‐methyl‐2 H ‐[1,4]benzoxazines

Author(s) -

Vakarov Sergey A.,

Chulakov Evgeny N.,

Sadretdinova Liliya Sh.,

Kodess Mikhail I.,

Ezhikova Marina A.,

Pervova Marina G.,

Ganebnykh Ilya N.,

Levit Galina L.,

Krasnov Victor P.

Publication year - 2020

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.202000629

Subject(s) - enantiopure drug , kinetic resolution , enantiomer , chemistry , stereoselectivity , resolution (logic) , stereochemistry , organic chemistry , catalysis , enantioselective synthesis , computer science , artificial intelligence

Stereoselectivity in the mutual kinetic resolution (KR) of racemic 3,4‐dihydro‐3‐methyl‐2 H ‐[1,4]benzoxazines and racemic 2‐aryloxy propionyl chlorides was studied. Based on the results obtained, preparative methods for single enantiomers of a series of 2‐aryloxy propionic acids via acylative KR of their racemates with enantiopure ( S )‐3,4‐dihydro‐3‐methyl‐2 H ‐[1,4]benzoxazines have been proposed.

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