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The Synthesis of 1 H ‐Pyrazolo[3,4‐ b ]quinoxaline Derivatives Oriented towards Modification of Carbocyclic Ring in the Parent Skeleton
Author(s) -
Wojtasik Katarzyna,
Danel Andrzej
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000418
Subject(s) - quinoxaline , diethylamine , chemistry , ring (chemistry) , derivative (finance) , stereochemistry , palladium , medicinal chemistry , catalysis , organic chemistry , financial economics , economics
Palladium catalyzed aminoarylation reactions are widely used to create new C−N bonds. It has been proved that the method of synthesis of 1 H ‐pyrazolo[3,4 ‐b ]quinoxaline derivatives (PQX), consisting of the reductive cyclization of the corresponding pyrazole derivative, is the most universal method of PQX synthesis among the known and is regiospecific. The obtained x‐chloro‐1‐methyl‐3‐phenyl‐1 H ‐pyrazolo[3,4‐ b ]quinoxaline isomers were starting materials for the synthesis of N,N ‐diethylamine derivatives. The position differentiation of these substituents strongly impact the emissive properties of the final compounds.