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FeCl 3 ‐Mediated Friedel‐Crafts Alkylation and Oxidative Annulations: Facile Synthesis of Benzofurans
Author(s) -
Zhang Xiongfei,
Zeng Piaopiao,
Zhang Shuo,
Chen Zhiwei
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000381
Subject(s) - chemistry , glyoxal , alkylation , anisole , benzofuran , atom economy , friedel–crafts reaction , organic chemistry , lewis acids and bases , tandem , combinatorial chemistry , catalysis , materials science , composite material
An efficient method for the facile synthesis of benzofurans through FeCl 3 ‐mediated intermolecular tandem reaction of anisole with glyoxal monohydrates was reported. This process provided the privileged structures of benzofurans in moderate to good yields under mild conditions. This reaction has many advantages, such as readily available starting materials, high atom economy and good functional group tolerance. This is firstly reported that FeCl 3 , acting as both a Lewis acid and an oxidant, was used for the synthesis of benzofuran.