Premium
Fabrication of High‐Performance Palladium Supported on Activated Charcoal Nanocatalyst for Synthesis of Morphine Opioid Analgesics
Author(s) -
Nazari Behzad,
Mousavi Sajjad,
Keshavarz Mohammad H.,
Bordbar AbdolKhalegh
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000337
Subject(s) - nanomaterial based catalyst , catalysis , palladium , nuclear chemistry , chemistry , fourier transform infrared spectroscopy , ethylene glycol , inorganic chemistry , chemical engineering , organic chemistry , engineering
Abstract High‐performance palladium supported on activated charcoal (Pd/AC H ) is an important nanocatalyst for the synthesis of different types of opioid analgesics. In this work, the Pd/AC H nanocatalysts are fabricated by a suitable method using the chemical reduction with ethylene glycol (EG), 1‐propanol, ethanol, and methanol, which act as reducing, stabilizing, and dispersing agents. Since this method does not require surfactants and reducing agents that are hazardous to the environment and human health, it is an environmentally friendly method. The activity of produced nanocatalysts was determined by catalytic hydrogenation of 14‐hydroxynormorphinone to noroxymorphone because noroxymorphone is the key active metabolite of oxycodone, noroxycodone, and oxymorphone. Among catalysts, it is specified that nanocatalyst prepared by EG (Pd/AC HEG ) has the highest activity. The effect of the EG for increasing the rate of Pd reduction is related to its high boiling point, which results in a decrease in particle size. The results of the reusability of the Pd/AC HEG nanocatalyst show that the activity of nanocatalyst is reduced by 12 % after four runs. Fourier‐transform infrared (FTIR), inductively coupled plasma (ICP), transmission electron microscopy (TEM), x‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET), x‐ray photoelectron spectroscopy (XPS), and H 2 chemisorption analyses were used for the analysis of Pd/AC H nanocatalysts.