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Mussel‐Inspired Surface Acrylation on Graphene Oxide Using Acrylic Surface Primers and Its Hydrogel‐Based Applications: Sustained Drug Release and Tissue Scaffolds
Author(s) -
Park Kyu Ha,
Jung Jaewon,
Yim SangGu,
Kang Mi Ju,
Kwon Gibum,
Hwang Dae Youn,
Yang Seung Yun,
Seo Sungbaek
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000205
Subject(s) - self healing hydrogels , ethylene glycol , graphene , drug delivery , chemical engineering , adsorption , materials science , oxide , adhesion , ethylene oxide , protein adsorption , swelling , chemistry , polymer chemistry , nuclear chemistry , nanotechnology , organic chemistry , polymer , composite material , copolymer , engineering
Composite hydrogels integrated with graphene oxide were prepared to enable the sustained release of loads for graphene‐based aromatic drug delivery and enhanced cell adhesion for tissue scaffolds. The surface of graphene oxide was readily transformed by the adsorption of acrylic surface primer (SP) without chemical reactions. The surface modification was verified by energy dispersive X‐ray spectroscopy and X‐ray diffraction spectra. The acrylated graphene oxide (SP‐GO) was photocrosslinked with acrylate groups of poly(ethylene glycol) to generate a composite hydrogel (SP‐GO hydrogel). Based on the molecular weight of poly(ethylene glycol), the hydrogels showed a swelling ratio range of ∼5–20, respectively. The SP‐GO did not change noticeably mechanical properties and inner structures of the hydrogels. Aromatic doxorubicin (DOX) was entrapped in the hydrogels with good yield and demonstrates the potential for a drug delivery carrier. The released DOX from the hydrogel containing SP‐GO (70.56% of entrapped DOX) exhibited a sustained release profile with reduced release after five days in a wet environment compared to the released DOX from a hydrogel without SP‐GO (92.29% of entrapped DOX). DOX is supposed to be attracted to graphene oxide and is physically entrapped inside the hydrogels. Moreover, bone MG‐63 cells entrapped in the SP‐GO hydrogel showed increased TGF‐β and fibronectin expression levels. This implies that SP‐GO contributes to enhancing cell growth and adhesion by providing cell‐laid structural support.