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An Efficient One‐Shot Metal‐Free Electrophilic Fluorination of 2‐Iminothiazolidine‐4‐one
Author(s) -
Appalanaidu Killari,
Dadmal Tulshiram L.,
Patil Suvarna M.,
Jagadeesh Babu N.,
Laxmikanth Rao J.,
Kumbhare Ravindra M.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202000189
Subject(s) - ethyl bromoacetate , electrophile , selectfluor , chemistry , isothiocyanate , aryl , reagent , combinatorial chemistry , organic chemistry , solvent , catalysis , alkyl
A highly efficient one‐pot method for the synthesis of mono fluorinated thiazolidinone derivatives have been achieved through four component reaction of primary amines, aryl isothiocyanates, ethyl bromoacetate and Selectfluor as electrophilic fluorinating agent. This protocol is practically convenient and offers the advantage of conducting easily handled sequenceof reaction in single reactor with suitable solvent medium. Reaction of primary amines with aryl isothiocyanate access forthiourea formation followed by addition of ethyl bromoacetate afforded the thiazolidinone, further on addition ofSelectfluor provides desired mono fluorinated products in short time with keen reaction procedure.