Premium
A BODIPY‐Hemicyanine‐Based Water‐Soluble Dual‐Color Fluorescence Probe for Colorimetric Monitoring of Intracellular Endogenous Sulfur Dioxide and Bioimaging Applications
Author(s) -
Liu Ying,
Wu YongXiang,
Zhang Dailiang,
Xi Yang,
Yu Shengrong,
Zhong Hongmei,
He Kangdi,
Li Dian,
Wei WenTing,
Cao Yuting,
Gan Ning
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904900
Subject(s) - bodipy , fluorescence , chemistry , endogeny , intracellular , nucleophile , aldehyde , photochemistry , sulfur dioxide , biophysics , biochemistry , organic chemistry , catalysis , biology , physics , quantum mechanics
We conjugated aldehyde‐BODIPY with the water‐soluble iodopropionic‐acid‐hemicyanine to develop a new dual‐color fluorescence probe (BHC) for selective and sensitive monitoring of endogenous SO 2 for the first time. Through excellent water solubility and the unique nucleophilic addition reaction, BHC has a higher selectivity for the colorimetric monitoring of SO 2 than other related substances. The resulting probe BHC has red emission, and can be converted to green emission after reacting with SO 2 . Then the dual‐color fluorescence probe was further applied to image intracellular endogenous generated SO 3 2− /HSO 3 − by the metabolism of living cells with satisfactory results. This strategy provides a new tool for revealing the metabolism of SO 3 2− /HSO 3 − and quantifying their distribution in living cells.