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Recent Progress on the Preparation of Cyclomatrix‐Polyphosphazene Based Micro/Nanospheres and Their Application for Drug Release
Author(s) -
Mehmood Sahid,
Wang Li,
Yu Haojie,
Haq Fazal,
Fahad Shah,
Alim Uddin Md,
Haroon Muhammad
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904844
Subject(s) - polyphosphazene , monomer , polymer , nanotechnology , polymer chemistry , materials science , chemistry , biocompatible material , chemical engineering , organic chemistry , biomedical engineering , medicine , engineering
Polyphosphazenes (PPZs) are the hybrid polymers composed of nitrogen and phosphorous atoms linked through alternate single and double bond. For the preparation of cyclomatrix polyphosphazene (CMPPZ) based micro/nanospheres, hexachlorocyclotriphosphazene (HCCP) was reacted with monomers containing hydroxyl and amino groups. The cross‐linked structure of CMPPZ is biodegradable and biocompatible in nature. The CMPPZ based micro/nanospheres have potential application in the field of biomedical. In this review article, we have described the different ways for the preparation of CMPPZ based micro/nanospheres and their drug release behavior. The average diameter size and surface morphology of the highly cross‐linked CMPPZ based micro/nanospheres depended on the concentration of both the monomers. This review article also emphasized on the drug release properties of the CMPPZ based micro/nanospheres.