Synthesis of 1 H ‐Indazoles and Quinazolines Using Additive Intermediates of Grignard Reagents to 2‐Amino Benzonitriles | Zendy

Zhao Huantian | Zendy; Huang Jiefang | Zendy; Zhang Jing | Zendy; Tang Yu | Zendy; Zhang Yuanming | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of 1 H ‐Indazoles and Quinazolines Using Additive Intermediates of Grignard Reagents to 2‐Amino Benzonitriles

Author(s) -

Zhao Huantian,

Huang Jiefang,

Zhang Jing,

Tang Yu,

Zhang Yuanming

Publication year - 2020

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201904794

Subject(s) - chemistry , yield (engineering) , reagent , grignard reagent , grignard reaction , combinatorial chemistry , medicinal chemistry , organic chemistry , materials science , metallurgy

We have developed a convenient and efficient approach to 1 H ‐indazoles in one pot under air atmosphere, using additive intermediates of Grignard reagents to 2‐aminobenzonitriles via a FeCl 3 /Bpy catalyzed N–N coupling. Besides, such intermediates could react with esters in one pot to yield quinazolines promoted by BiCl 3 /Ph 3 P. Both 1 H ‐indazoles and quinazolines were prepared in good to excellent yields. The possible mechanisms for the formation of 1 H ‐indazoles and quinazolines were proposed.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research