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Preparation of Inverse Opal Hydroxyapatite and Drug Delivery Properties
Author(s) -
Wang Lili,
Zhou Yemin,
Wang Xiufeng,
Feng Lina,
Liu Xinxin
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904766
Subject(s) - drug delivery , dispersant , materials science , inverse , porosity , chemical engineering , polystyrene , drug , nanotechnology , chromatography , chemistry , composite material , dispersion (optics) , polymer , mathematics , pharmacology , medicine , physics , geometry , engineering , optics
Hydroxyapatite(HA) are widely used in the field of drug delivery, especially nano‐HA and porous HA. However, there are few reports on the use of inverse opal HA as drug carrier. In this paper, based on the colloidal crystal template prepared by polystyrene microsphere with the diameter of 380 ± 10 nm, inverse opal HA was prepared by template method as the drug sustained‐release carrier using different dispersants and ratio of template to precursor. The results indicated that when the ratio of template to precursor was 1 : 15 and the dispersant was a mixture of water and alcohol, the prepared inverse opal HA showed a complete ordered porous morphology with uniform pore spacing. In the drug delivery test of amoxicillin, the drug loading and release properties of the inverse opal HA were significantly better than that of nano‐HA. The drug loading of the inverse opal HA was about 2.17 times of nano‐HA, and the drug‐loading performance was also obviously improved. At the same time, sustained release ability of the inverse opal HA was better than that of nano‐HA when releasing amoxicillin. In the first 3 h, the cumulative release rate of amoxicillin on the inverse opal HA was less than 40%, much lower than about 60% of nano‐HA, significantly slowing down the drug release rate and showing good persistence. Therefore, the inverse opal HA as a drug carrier could also improve the sudden release effect of the drug and make the release rate gentler.