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Rh(III)‐Catalyzed C−H Acylmethylation of 6‐Arylpurines Using Sulfoxonium Ylides as Carbene Precursors
Author(s) -
Chen Zhibing,
Kong Xianqiang,
Xu Bo
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904754
Subject(s) - carbene , regioselectivity , catalysis , chemistry , aryl , purine , functional group , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , alkyl , enzyme , polymer
We have developed an efficient acylmethylation of C6 aryl‐ purines via C–H bond activation using the readily available sulfoxonium ylides as carbene precursors. The purine motif is the direction group. Our Rh‐catalyzed acylmethylation offers excellent chemical yields and regioselectivity with good functional group tolerance.