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A Catalyst‐Free Synthetic Route to Modified Isoflavone via Multi‐Component Reaction
Author(s) -
Alizadeh Abdolali,
Bagherinejad Akram
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904674
Subject(s) - malononitrile , knoevenagel condensation , catalysis , yield (engineering) , chemistry , carbanion , combinatorial chemistry , solvent , condensation reaction , component (thermodynamics) , organic chemistry , isoflavonoid , materials science , physics , flavonoid , metallurgy , thermodynamics , antioxidant
A concise and efficient one‐pot sequential approach for the synthesis of modified isoflavone was developed from a reaction of 3‐formylchromones, malononitrile, various α , α ‐dicyanoolefines, using Et 3 N as the base, and EtOH as the solvent, in good yield. The value of this method lies in its short reaction time, convenient purification, no need for a metal catalyst, excellent efficiency, and green solvent. This synthesis involves a Knoevenagel condensation/carbanion formation/ring closure, and finally , an elimination to obtain the respective isoflavonoid derivatives.
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