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Efficient Synthesis, Antibacterial, Antifungal, Antioxidant and Cytotoxicity Study of 2‐(2‐Hydrazineyl)thiazole Derivatives
Author(s) -
Adole Vishnu A.,
More Rahul A.,
Jagdale Bapu S.,
Pawar Thansing B.,
Chobe Santosh S.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904609
Subject(s) - thiazole , chemistry , green chemistry , cytotoxicity , yield (engineering) , proton nmr , combinatorial chemistry , solvent , organic chemistry , antimicrobial , carbon 13 nmr , antioxidant , antifungal , limiting , peg ratio , reaction mechanism , materials science , in vitro , catalysis , biochemistry , medicine , mechanical engineering , finance , dermatology , economics , engineering , metallurgy
In the present investigation, an alluring green PEG‐400 mediated one‐pot synthesis of novel 2‐(2‐hydrazinyl)thiazole derivatives from 1,2,6,7‐tetrahydro‐8 H ‐indeno[5,4‐ b ]furan‐8‐one has been unveiled via a novel synthetic pathway. The application of PEG in organic reactions as a reaction media is one of the fantastic tools of green chemistry as reactions can be carried out under generous conditions limiting environmental peril and chemical waste. PEG‐400 is recognized as a low‐cost, non‐flammable, environmentally benign, recyclable, and richly available green solvent. A series of novel 2‐(2‐hydrazineyl)thiazole derivatives have been synthesized in good to excellent yield by using the green capability of PEG‐400 solvent. These newly synthesized compounds were tested for their antimicrobial and antioxidant activities. The results revealed that these compounds show good activities compared with the standard. Additionally, all the synthesized compounds exhibit negligible cytotoxicity as compared to the positive control. The structures of all novel compounds reported herein are established using FT‐IR, 1 H NMR, 13 C NMR, D 2 O exchange experiment and HRMS techniques.