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An Electrochemical Approach for the Direct Synthesis of 3, 5‐Disubstituted 1, 2, 4‐Triazoles from Nitriles and Hydrazides
Author(s) -
Singh Manjula,
Kant Sharma Laxmi,
Dubey Rahul,
Kumar Patel Manoj,
Prakash Ved,
Krishna Pal Singh Rana
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904510
Subject(s) - electrochemistry , computer science , environmentally friendly , protocol (science) , redox , combinatorial chemistry , simple (philosophy) , anode , oxidation reduction , chemistry , organic chemistry , electrode , medicine , ecology , philosophy , biochemistry , alternative medicine , pathology , epistemology , biology
A highly facile, efficient and environmentally friendly protocol for the first electrochemical synthesis of 3, 5‐disubstituted 1, 2, 4‐triazoles from nitriles and hydrazides is reported. The reaction efficiency involves anodic oxidation and cathodic reduction, and has a good functional group tolerance. This synthetic approach is operationally simple and gives good to excellent yields under mild conditions in a one‐pot procedure. It utilizes KI as the redox catalyst under external oxidant‐free conditions.