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A Facile Regioselectively Synthesis of 2‐Alkenylbenzo[1,2‐ b:4,5‐b’ ]dithiophene by Pd/Cu/Ag‐Catalyzed C‐H Functionalization
Author(s) -
Dung Tran Ngoc,
Van Trang Nguyen,
Thanh Dinh Thi Mai,
Van Khanh Nguyen Thi,
Nguyen Hien,
Nguyen Hue Minh Thi
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904411
Subject(s) - regioselectivity , surface modification , catalysis , chemistry , stereochemistry , combinatorial chemistry , materials science , organic chemistry
In this work, several alkenylated benzo[1,2‐ b :4,5‐ b′ ]dithiophene were synthesized by Pd‐catalyzed C−H functionalization of benzo[1,2‐ b :4,5‐ b′ ]dithiophene with various alkenes. This direct alkenylation took place regioselectively at the C‐2 position of the fused heterocycle. The obtained compounds were structurally characterized by NMR and MS spectroscopic methods. Moreover, DFT calculations have been employed to shed light on the regioselectivity of the reaction as well as on the geometry and electronic properties of the newly formed C=C double bonds.