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Generalising a Simple Methodology for the Regioselective Anomeric Deacetylation of Carbohydrates
Author(s) -
Hattie Mitchell,
Stubbs Keith A.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904343
Subject(s) - anomer , regioselectivity , acetylation , methylamine , carbohydrate , simple (philosophy) , chemistry , organic chemistry , combinatorial chemistry , biochemistry , catalysis , philosophy , epistemology , gene
The use of methylamine to deprotect 1‐ O ‐acetyl protected carbohydrates has only attracted limited interest in the literature. Demonstrated here is an approach that is able to be generalized for a wide variety of carbohydrate scaffolds which results in a high yielding, simplified, practical, expedient and clean method to prepare hemiacetals from 1‐ O ‐acetyl protected carbohydrates.
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