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Fabrication of CS/SA Double‐Network Hydrogel and Application in pH‐Controllable Drug Release
Author(s) -
Li Yuanze,
Wang Haili,
Niu Yuzhong,
Ma Songmei,
Xue Zhongxin,
Song Aixin,
Zhang Shaohua,
Xu Wenlong,
Ren Chunguang
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904325
Subject(s) - self healing hydrogels , chitosan , microstructure , fabrication , materials science , chemical engineering , scanning electron microscope , network structure , nanotechnology , composite material , polymer chemistry , computer science , medicine , alternative medicine , pathology , machine learning , engineering
In order to promote the application range, double‐network hydrogels are usually fabricated to improve the mechanical properties. In this work, chitosan (CS) single‐network hydrogels were prepared firstly and sodium alginate (SA) was introduced as the second network. According to scanning electron microscopy (SEM), the microstructures of the CS and SA single‐network were identified as three‐dimensional network of pore and fiber structure, respectively. The microstructure maintained the pore structure after the formation of CS/SA double‐network due to the small amount of SA. The size of the pores was reduced, indicating the cross‐linking of the double‐network. The rheological results indicated that CS/SA double‐network with small amount of SA could enhance the mechanical strength of the hydrogel effectively. Finally, the in vitro release was operated, verifying the sustained release ability of the double‐network hydrogel. In addition, only small amount of the drug could be release in physiological environment (pH 7.4), while a quickly release was obtained in pathological tissue (pH 5.5), decreasing the side effect of the drug.