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Synthesis of 1,2,3‐Triazole Tethered 3‐Hydroxy‐2‐oxindoles: Promising Corrosion Inhibitors for Steel in Acidic Medium and Their Anti‐Microbial Evaluation
Author(s) -
Sampath Sugirdha,
Vadivelu Murugan,
Ravindran Radhika,
Perumal Paramasivan T.,
Velkannan Veerapandian,
Karthikeyan Kesavan
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904320
Subject(s) - tafel equation , isatin , corrosion , propargyl , triazole , chemistry , propargyl alcohol , combinatorial chemistry , adsorption , gravimetric analysis , corrosion inhibitor , antimicrobial , electrochemistry , nuclear chemistry , 1,2,3 triazole , organic chemistry , catalysis , electrode
Herein, we designed and synthesizeda series of 1,2,3‐triazole tethered 3‐hydroxy‐2‐oxindoles ( 4 a‐j ) using N ‐propargyl isatin derivatives as key starting materials ( 1 a‐d ) under ball‐milling conditions by merging aldol condensation and click reaction. The synthesized compounds ( 4 a‐j ) were examined for their corrosion inhibition behavior in mild steel using gravimetric and electrochemical analysis. The compound 4 i was identified as the most efficient compound with an efficiency of >70%. Also, the adsorption of inhibitors on the surface of mild steel and mixed type of behaviors was evidenced by impedance and Tafel polarization studies, respectively. Further, the evaluation of antibacterial and antifungal activities demonstrated that compound 4 g possessed a significant potential to behave as an antimicrobial agent.