Premium
Biofabrication of Diatom Surface by Tyrosine‐Metal Complexes:Smart Microcontainers to Inhibit Bacterial Growth
Author(s) -
Singh Ramesh,
Khan Mohd Jahir,
Rane Jagdish,
Gajbhiye Ashmita,
Vinayak Vandana,
Joshi Khashti Ballabh
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904248
Subject(s) - diatom , bacterial cell structure , bacteria , zinc , chemistry , biofabrication , bacterial growth , biophysics , nanotechnology , biology , biochemistry , materials science , botany , organic chemistry , tissue engineering , genetics
This study explores the potential of a highly biocompatible golden brown algal cell, diatom, as a drug carrier to the bacterial cell. The strong interaction between diatom and bacteria that occur in the microenvironment, lead us to pave the way for exciting new directions where diatom can be used to address several bacterial infections. The surface of diatom frustules was modified with self‐assembled antibacterial aromatic amino acid conjugates, Tyr‐Zn II . Microscopy and spectroscopy observations confirmed the deposition of Tyr‐Zn II over diatom frustules. Diatoms can work as living microcontainers to store the toxic metal (drug) ions and therefore can be utilized as potential drug delivery agents to kill the clinically relevant bacteria. Due to antibacterial property of zinc ions, Tyr‐Zn II conjugates inhibits bacterial growth and diatom frustules were utilized as Tyr‐Zn II carrier for controlled release of zinc to the bacterial cell.