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Palladium‐Catalyzed Intermolecular Carbopalladation Cascade: Facile Synthesis of [1,2,3]Triazolo[1,5‐ a ]quinolines from o ‐Triazole Bromobenzenes and Internal Alkynes
Author(s) -
Qiu Huihua,
Zhou Peng,
Liu Weibing,
Zhang Jiantao,
Chen Baoning
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904238
Subject(s) - annulation , palladium , intermolecular force , cascade , chemistry , combinatorial chemistry , catalysis , triazole , functional group , scope (computer science) , stereochemistry , organic chemistry , molecule , computer science , polymer , chromatography , programming language
A palladium‐catalyzed intermolecular annulation and arylation cascade between internal alkynes and o ‐triazole bromobenzenes was developed, delivering to various polysubstituted [1,2,3]triazolo[1,5‐ a ]quinolines. Broad substrate scope, great functional group tolerance and simple operation of this transformation, hold great synthetic potential for the rapid construction of fused N‐heterocycles with biologically activity.