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Synthesis and Antiproliferative Evaluation of 5′‐Arylchalcogenyl‐3‐(phenylselanyl‐triazoyl)‐thymidine
Author(s) -
Quoos Natália,
Dornelles Luciano,
Buss Julieti,
Begnini Karine Rech,
Collares Tiago,
Seixas Fabiana K.,
Garcia Fabio Dutra,
Rodrigues Oscar E. D.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201904076
Subject(s) - thymidine , in vitro , nucleoside , chemistry , molecule , combinatorial chemistry , stereochemistry , cancer research , biology , biochemistry , organic chemistry
This article discloses the synthesis and biological in vitro activity of a novel class of compounds derived from 5′‐arylchalcogenyl‐3‐(phenylselanyl‐triazoyl)‐thymidine as antitumor agents in the 5637 bladder carcinoma. The synthesis of the new molecules obtained good yields and proved to be efficient. The antitumor biological property, which was presented by a series of these unpublished compounds, demonstrates the importance of the presence of the nucleoside portion and the chalcogenium atom in the molecule.