Premium
Ascorbic Acid as an Efficient Organocatalyst for the Synthesis of 2‐Substituted‐2,3‐dihydroquinazolin‐4(1 H )‐one and 2‐Substituted Quinazolin‐4(3 H )‐one in Water
Author(s) -
Chandra Pariyar Gyan,
Mitra Bijeta,
Mukherjee Suvodip,
Ghosh Pranab
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903937
Subject(s) - ascorbic acid , chemistry , catalysis , aldehyde , organic chemistry , hazardous waste , solvent , combinatorial chemistry , protocol (science) , medicine , alternative medicine , food science , pathology , ecology , biology
An environmentally benign, robust and straightforward protocol has been developed for the synthesis of a diverse array of 2,3‐dihydroquinazolin‐4(1 H )‐ones using 2‐aminobenzamide and various aldehydes or ketones. Water, a green solvent was adopted in this methodology replacing hazardous reaction mediums. Further, ascorbic acid, an organocatalyst has been accepted to meet the role of catalyst, thus bypassing the use of noxious metals or hazardous materials, which is another asset of this protocol. The activity of this novel methodology has been further being broadened using an oxidant oxone to synthesize 2‐substituted quinazolin‐4(3 H )‐one from aldehyde.