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Electrochemical Synthesis of β ‐Ketonitriles from Aryl Methyl Ketones
Author(s) -
Yavari Issa,
Shaabanzadeh Sina,
Sheikhi Sara
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903931
Subject(s) - cyanation , electrochemistry , cyanide , aryl , chemistry , iodide , anode , anodic oxidation , metal , combinatorial chemistry , inorganic chemistry , organic chemistry , electrode , catalysis , alkyl
A synthesis of β ‐ketonitriles by cyanation of aryl methyl ketones with two completely distinct sources of cyanide, namely Me 3 SiCN and KCN, under metal‐ and oxidant‐free electrochemical anodic oxidation conditions is described. In this approach, a range of β ‐ketonitriles can be obtained in good yields. This conversion is facilitated by I 2 , generated in situ from electrochemical oxidation of iodide ion to afford the β ‐ketonitriles. This environmentally benign method is more convenient and practical compared to previous approaches.