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Orthoesters: Multiple Role Players in Organic Synthesis
Author(s) -
Nazarian Zohreh,
Dabiri Minoo
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903901
Subject(s) - nucleophile , alkoxy group , organic synthesis , chemistry , group (periodic table) , stereoselectivity , combinatorial chemistry , masking (illustration) , carbon atom , functional group , organic chemistry , catalysis , ring (chemistry) , polymer , alkyl , visual arts , art
Orthoesters are characterized by three alkoxy groups attached to a single carbon atom. This functional group is used primarily as a masking group for carboxylic acids, due to its robust stability towards strong nucleophiles and bases. Besides this protection role, orthoesters have further utility as versatile precursors in organic synthesis. This review focuses on the latter role of orthoesters as well as their applications in stereoselective synthesis.