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Catalyst‐Free α‐Aminoxylation of 1,3‐Dicarbonyl Compounds with TEMPO Using Selectfluor as an Oxidant
Author(s) -
Tang Lin,
Yang Zhen,
Yang Fang,
Huang Yifan,
Chen Hanfei,
Cheng Hao,
Song Weiyan,
Ren Bo,
Zhou Qiuju
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903856
Subject(s) - selectfluor , catalysis , regioselectivity , substrate (aquarium) , chemistry , combinatorial chemistry , reaction conditions , organic chemistry , biology , ecology
A catalyst‐free and regioselective α‐aminoxylation of 1,3‐dicarbonyl compounds with TEMPO by use of Selectfluor as a mild oxidant has been demonstrated, yielding the corresponding alkoxyamines in good to excellent yields. The developed protocol features no employment of a catalyst, broad substrate scope and mild reaction conditions, which enables a convenient and efficient avenue for quaternary C–O bond formation.