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Facile, High‐Yielding Synthesis of 4‐Functionalised 1,2,3‐Triazoles via Amino‐ and Aryloxycarbonylation
Author(s) -
Szuroczki Péter,
Molnár Levente,
Dörnyei Ágnes,
Kollár László
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903801
Subject(s) - reagent , azide , nucleophile , chemistry , cycloaddition , alkyne , halogenation , combinatorial chemistry , click chemistry , organic chemistry , high pressure , medicinal chemistry , catalysis , engineering physics , engineering
4‐Iodo‐1,2,3‐triazoles were synthesised via azide‐alkyne cycloaddition of alkynyl Grignard reagent and benzyl azide followed by iodination reaction. The aminocarbonylation and aryloxycarbonylation of 4‐iodo‐1,2,3‐triazoles were carried out in the presence of various N ‐ and O ‐nucleophiles, resulting in the corresponding triazole‐based 4‐carboxamides and 4‐esters, respectively. Both high‐yielding reactions were carried out under mild conditions (atmospheric CO pressure, 70 °C).