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Superbase‐Promoted N ‐α‐sp 3 C‐H Functionalization of Tertiary Enaminones: Synthesis of Polysubstituted Pyrroles
Author(s) -
Xu Limei,
Wu Longqiao,
Chen Ting,
Xu Shuang,
Huang Chuiting,
Wang Yanyun,
You Qihua,
Shen Jinhai
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903792
Subject(s) - superbase , surface modification , yield (engineering) , scope (computer science) , chemistry , substrate (aquarium) , atom economy , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , materials science , computer science , biology , metallurgy , programming language , ecology
An efficient superbase‐promoted N ‐α‐sp 3 C−H functionalization of tertiary enaminones for the regiospecific synthesis of structurally diversified pyrroles under mild conditions has been exploited. The developed methodology led to a wide panel of pyrroles with broad substrate scope in an atom‐economy manner. Various substituted pyrroles are provided in up to 94% yield for 36 examples.