Superbase‐Promoted  N ‐α‐sp 3 C‐H Functionalization of Tertiary Enaminones: Synthesis of Polysubstituted Pyrroles | Zendy

Xu Limei | Zendy; Wu Longqiao | Zendy; Chen Ting | Zendy; Xu Shuang | Zendy; Huang Chuiting | Zendy; Wang Yanyun | Zendy; You Qihua | Zendy; Shen Jinhai | Zendy

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Superbase‐Promoted N ‐α‐sp 3 C‐H Functionalization of Tertiary Enaminones: Synthesis of Polysubstituted Pyrroles

Author(s) -

Xu Limei,

Wu Longqiao,

Chen Ting,

Xu Shuang,

Huang Chuiting,

Wang Yanyun,

You Qihua,

Shen Jinhai

Publication year - 2020

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201903792

Subject(s) - superbase , surface modification , yield (engineering) , scope (computer science) , chemistry , substrate (aquarium) , atom economy , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , materials science , computer science , biology , metallurgy , programming language , ecology

An efficient superbase‐promoted N ‐α‐sp 3 C−H functionalization of tertiary enaminones for the regiospecific synthesis of structurally diversified pyrroles under mild conditions has been exploited. The developed methodology led to a wide panel of pyrroles with broad substrate scope in an atom‐economy manner. Various substituted pyrroles are provided in up to 94% yield for 36 examples.

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