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Thiamine Hydrochloride Catalyzed Synthesis of 1,2,4‐Triazolidine‐3‐thiones in Aqueous Medium
Author(s) -
Patil Pradeep J.,
Salunke Govind D.,
Deshmukh Madhukar B.,
Hangirgekar Shankar P.,
Chandam Dattatray R.,
Sankpal Sandeep A.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903646
Subject(s) - catalysis , chemistry , atom economy , aqueous medium , hydrochloride , aqueous solution , thiamine , yield (engineering) , organic chemistry , aryl , combinatorial chemistry , materials science , alkyl , metallurgy
Abstract In the present work, the catalytic potential of natural organocatalyst thiamine hydrochloride is explored for the synthesis of 1,2,4‐triazolidine‐3‐thiones in aqueous medium. The reaction of thiosemicarbazides with various substrates viz aryl/ heteroaryl aldehydes, isatins, cyclic and aromatic ketones to obtain corresponding 1,2,4‐triazolidine‐3‐thiones have been successfully demonstrated for the first time. The method proposed in this work addresses the green chemistry principles such as biodegradable catalyst, ambient reaction condition, shorter reaction time, high yield of the products, recyclability of catalyst and high atom economy.