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Base‐Promoted Metal‐Free Arylation of Benzoxazoles with Phenylglyoxylic Acids
Author(s) -
Yang Zhiyong,
Zhou Liang,
Liu Ying,
Lu Hongwen,
Wu Fengxuan,
Xie Yuxin,
Liu Jianle
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903641
Subject(s) - chemistry , base (topology) , aryl , combinatorial chemistry , transformation (genetics) , protocol (science) , organic chemistry , biochemistry , mathematics , medicine , mathematical analysis , alkyl , alternative medicine , pathology , gene
An efficient and environmental protocol for the arylation of benzoxazoles with phenylglyoxylic acids promoted by base has been developed. This protocol provides expedient access to substituted 2‐aryl benzoxazoles with CO 2 as the only byproduct. The present transformation provided high yields at a relatively low temperature and tolerated chloro‐, bromo‐, fluoro‐, and methoxy‐ groups, even heterocycles.