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Synthesis of Gemini‐QA N ‐Chloramine Biocides for Antibacterial Applications
Author(s) -
Li Lingdong,
Wang Hande,
Jia Dongxue,
Wang Pengfei
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903585
Subject(s) - chloramine , biocide , cationic polymerization , ammonium , chemistry , antibacterial activity , chloramine t , covalent bond , combinatorial chemistry , chlorine , bacteria , organic chemistry , biology , genetics
Gemini‐quaternary ammonium (QA) N ‐chloramines were synthesized by covalently bonding two N ‐chloramine units via a Gemini‐QA core with varied alkyl linkers. Preliminary antibacterial tests showed that Gemini‐QA N ‐chloramine exerted superior biocidal efficacy in contrast to previous developed QA N ‐chloramine counterpart probably by means of “team effort” contact killings. Futhermore, the analog with linker of ‐(CH 2 ) 10 ‐ exhibited the highest antibacterial efficacy probably caused by its favorable membrane penetration. This work may provide vital references to develop multi‐cationic N ‐chloramines with even higher biocidal activity, which may be indispensable for combateing with bacteria resiatance.