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Cu‐NHC‐Catalyzed Enantioselective Conjugate Silyl addition to Indol‐1‐ylacrylate Derivatives
Author(s) -
Shen JunJian,
Gao Qian,
Wang Guangzhu,
Tong Min,
Chen Lili,
Xu Senmiao
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903570
Subject(s) - conjugate , enantioselective synthesis , silylation , indole test , chemistry , catalysis , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , mathematics , mathematical analysis
Cu‐catalyzed enantioseletive conjugate addition of a dimethylphenylsilyl group to indol‐1‐ylacrylate derivatives was established using N‐Heterocyclic Carbenes (NHCs) as the ligands. The reaction was efficient for a wide range of indole derivatives bearing eletron‐donating and electron‐withdrawing group, and proceeded under mild condition. Good levels of enantioselectivity were also observed for diverse carbonyl derivatives.