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Isopropyl Cresols: Synthesis and Herbicidal Activity
Author(s) -
Wang Jing,
Dong Huanhuan,
Zhang Hongmei,
Dai Songlin,
Jiang Jianxin,
Zhao Zhendong
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903550
Subject(s) - isopropyl , thymol , chemistry , carvacrol , isopropyl alcohol , isomerization , monoterpene , catalysis , organic chemistry , chromatography , essential oil , antimicrobial
Abstract Isopropyl cresols were prepared by a two‐step process: monoterpene oxidation catalyzed by CrO 3 and terpenone isomerization catalyzed by 13X molecular sieves. 5‐Isopropyl‐3‐methylphenol and carvacrol were prepared from 3‐carene, whereas thymol and 4‐isopropyl‐3‐methylphenol were synthesized from α ‐pinene. The two reactions followed an identical procedure, but the reaction of 3‐carene was more efficient, benefiting from the three‐membered ring in the structure. 5‐Isopropyl‐3‐methylphenol, thymol, and carvacrol were found to show higher herbicidal activity than glyphosate toward the root growth of barnyard grass. However, they exhibited slightly lower activity in preventing shoot growth. Moreover, 5‐isopropyl‐3‐methylphenol showed higher herbicidal activity than its isomers, which indicates that the relative position of substitutes is significantly associated with the herbicidal activity of isopropyl cresols.