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Ascorbyl‐6‐O‐oleate: A Bioconjugate Antioxidant Lipid
Author(s) -
Perini Ilaria,
Ambrosi Moira,
Tanini Damiano,
Ninham Barry W.,
Capperucci Antonella,
Nostro Pierandrea Lo
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903528
Subject(s) - chemistry , antioxidant , differential scanning calorimetry , fourier transform infrared spectroscopy , bioconjugation , oleic acid , molecule , small angle x ray scattering , organic chemistry , nuclear chemistry , combinatorial chemistry , chemical engineering , biochemistry , scattering , physics , optics , engineering , thermodynamics
Ascorbyl‐6‐O‐oleate (Asc‐OL) was synthesized enzimatically and studied in the pure state and in aqueous dispersions. Small‐angle X‐ray scattering (SAXS), differential scanning calorimetry (DSC), Fourier transformed infrared (FTIR) spectroscopy experiments and antioxidant tests were conducted in order to characterize the compound and to evaluate its reducing properties. Asc‐OL is a bioconjugate molecule, in fact it combines the main physico‐chemical features of the two parent molecules, i. e. the redox and acidic properties of Vitamin C and the fluid‐like state of oleic acid. The appropriate tests were carried out to confirm the excellent radical scavenging activities of Asc‐OL, that turned out to be a promising candidate for the stabilization, transport and protection against radical attack of valuable hydrophobic active ingredients used in food and pharmaceutical formulations.