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Hybrid Molecules Based on C 60 Fullerene and 5Z,9Z‐Dienoic Acids: Synthesis and Cytotoxic Activity
Author(s) -
Tuktarov Airat R.,
Khuzina Liliya L.,
Akhmetov Arslan R.,
Tuktarova Regina A.,
Ishmukhametova Svetlana R.,
Dzhemileva Lilya U.,
D'yakonov Vladimir A.,
Dzhemilev Usein M.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903525
Subject(s) - jurkat cells , cytotoxic t cell , molecule , cytotoxicity , stereochemistry , chemistry , in vitro , hl60 , combinatorial chemistry , biology , organic chemistry , biochemistry , t cell , immunology , immune system
The present research addresses synthesis of methanofullerenes containing 5Z,9Z‐dienoic acid molecules applying the Bingel and Bingel‐Hirsch reactions. The cytotoxic activity of the synthesized methanofullerenes against Jurkat, K562, U937, HL60 tumour cells was under study. Hybrid methanofullerenes containing dienoic acids were found to exhibit high in vitro cytotoxicity against these tumour cell lines, produce phase‐specific cytotoxic effect during the S and G2 phases of the cell cycle, and are also effective inducers of apoptosis.