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Metal‐Organic Frameworks of Cu 3 (BTC) 2 Catalyzed Cascade C‐H Activation/C‐S Coupling/C‐O Cyclization Reaction Strategy: One‐Pot Efficient Synthesis of Phenoxathiines
Author(s) -
Liu Na,
Chao Fei,
Yan Jiaying,
Huang NianYu,
Ren ZhiLin,
Wang Long
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903494
Subject(s) - cascade , catalysis , yield (engineering) , chemistry , intramolecular force , cascade reaction , coupling (piping) , metal , hydroxylation , coupling reaction , reaction conditions , combinatorial chemistry , reaction mechanism , medicinal chemistry , stereochemistry , materials science , organic chemistry , chromatography , metallurgy , enzyme
A novel synthetic strategy of cascade C−H activation/C−S coupling/C−O cyclization reaction by using metal organic framework material Cu 3 (BTC) 2 as catalyst is investigated. In this method, Cu 3 (BTC) 2 can effectively catalyze the hydroxylation of the ortho ‐C sp2 ‐H of benzenethiol, and then the coupling reaction and intramolecular C−O coupling cyclization. Phenoxathiine derivatives are efficiently prepared by one‐pot method. In our work, a series of phenoxathiin derivatives were obtained in good yield by this method. At the same time, the reaction mechanism was explored through conditional control experiments.