Premium
Click‐Derived Uracil‐Appended Organosilatranyl Scaffolds: Synthesis, Antibacterial Characteristics, Pb2+ Binding and Fabrication of Hybrid Silica Nanoparticles
Author(s) -
Singh Gurjaspreet,
Sharma Geetika,
Kalra Pooja,
Satija Pinky,
Singh Baljinder,
Aulakh Darpandeep,
Wreidt Mario
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903464
Subject(s) - uracil , covalent bond , click chemistry , fluorescence , nanoparticle , grafting , chemistry , combinatorial chemistry , chemical engineering , hybrid material , materials science , nanotechnology , organic chemistry , dna , biochemistry , physics , quantum mechanics , engineering , polymer
Using a simple biocompatible click route Uracil Allied Organosilatranyl frameworks ( 4 a – 4 e ) have been obtained. These uracil tethered silatranes have shown judicious fluorescence as compared to the parent nitrogen heterocycle uracil. Through absorption and fluorescence spectral measurements, it was established that the designed analogues were selective towards Pb 2+ recognition. Furthermore, for the first time hybrid silica nanoparticles (U‐SiNPs) containing a uracil bis‐triazole linkage in the silica framework is reported. The fabricated organosilatrane ( 4 d ) was subjected to sol‐gel condensation with silica nanospheres for covalent grafting of the organic functionality on to silica. It was of interest that the uracil immobilized nanoparticles presented a high sensing efficacy towards Pb 2+ as compared to the bulk material. Also, to investigate their biological potential, organosilatranes were evaluated against different bacterial strains.