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Efficient and Chemoselective Amidation of β ‐Carboline Carboxylic Acids
Author(s) -
Lin Miaoman,
Liang Weida,
Ma Jiale,
Wu Ye,
Xiao Xiao,
Ying Jianxi,
Yan Yinghua,
Zhao Lingling,
Jin Haixiao,
Liang Hongze,
Cui Wei,
Yan Xiaojun
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903444
Subject(s) - amide , amine gas treating , chemistry , carboxylic acid , neuroprotection , combinatorial chemistry , organic chemistry , pharmacology , biology
Abstract A series of β ‐carboline amides has been synthesized in one‐pot reaction via coupling between an acid and an amine in the presence of HBTU/Et 3 N. This mild amidation reaction undergoes efficiently and chemoselectively. Bioactivity studies indicate that the β ‐carboline amide derivatives exhibit neuroprotective activity and might be developed to be lead compounds for anti‐stroke agents.