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Synthesis and Pharmacological Evaluation of Some Amide Functionalized 1 H ‐Benzo[ d ]imidazole‐2‐thiol Derivatives as Antimicrobial Agents
Author(s) -
Singu Padma S.,
Kanugala Sirisha,
Dhawale Sachin A.,
Kumar C. Ganesh,
Kumbhare Ravindra M.
Publication year - 2020
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903380
Subject(s) - antimicrobial , imidazole , thiol , benzimidazole , amide , chemistry , biofilm , combinatorial chemistry , antibacterial activity , stereochemistry , organic chemistry , bacteria , biology , genetics
A series of novel amide functionalized 1 H ‐benzo[d]imidazole‐2‐thiol derivatives 4 a‐o were prepared from substituted benzimidazole‐2‐thiol 1 a‐c . All the final compounds were screened for antimicrobial, minimum bactericidal concentration (MBC) and anti‐biofilm activities against Gram‐positive and Gram‐negative bacterial strains. Amongst all the synthesized derivatives, compounds 4 c , 4 e , 4 f , 4 g , 4 k and 4 o exhibiting promising antibacterial activity against various bacterial strains were identified. Moreover, the compound 4 c showed highly significant antimicrobial activity (MIC value of 1.9 μg/mL) and broad‐spectrum anti‐biofilm activity which was identified as a potential lead molecule.