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Synthesis of 2‐Alkynyl‐ and2‐Amino‐12 H ‐benzothiazolo[2,3‐ b ]quinazolin‐12‐ones and Their Inhibitory Potential against Monoamine Oxidase A and B
Author(s) -
Jafari Behzad,
Jalil Saquib,
Zaib Sumera,
Safarov Sayfidin,
Khalikova Muattar,
Khalikov Djurabay,
Ospanov Meirambek,
Yelibayeva Nazym,
Zhumagalieva Shynar,
Abilov Zharylkasyn A.,
Turmukhanova Mirgul Z.,
Kalugin Sergey N.,
Salman Ghazwan Ali,
Ehlers Peter,
Hameed Abdul,
Iqbal Jamshed,
Langer Peter
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903300
Subject(s) - monoamine oxidase , chemistry , monoamine oxidase b , monoamine neurotransmitter , stereochemistry , inhibitory postsynaptic potential , aryl , combinatorial chemistry , pharmacology , enzyme , biochemistry , serotonin , organic chemistry , medicine , receptor , alkyl
2‐Alkynyl‐ and 2‐aminobenzothiazolo[2,3‐ b ]quinazolin‐12‐ones have been synthesized by Palladium catalysed Buchwald‐Hartwig and Sonogashira reactions. Synthesized derivatives were further evaluated for their role as potential inhibitors of monoamine oxidase A and B (MAO−A and B) isozymes. Most compounds possess moderate to excellent inhibitory potential against MAO−A and MAO−B. The 2‐amino‐substituted derivatives show a significantly higher activity as compared to 2‐alkynyl‐ and previously reported 2‐aryl derivatives. Studied compounds might be employed as novel monoamine oxidase inhibitors and may provide insights for the development of new drug candidates against neurological diseases.