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Novel Platinum(II) Complexes Selectively Induced Apoptosis and Cell Cycle Arrest of Breast Cancer Cells In Vitro
Author(s) -
Marković Nenad,
Zarić Milan,
Živković Marija D.,
Rajković Snežana,
Jovanović Ivan,
Arsenijević Nebojša,
Čanović Petar,
Ninković Srđan
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201903290
Subject(s) - chemistry , oxaliplatin , cisplatin , cytotoxicity , denticity , apoptosis , in vitro , selectivity , ethylenediamine , platinum , stereochemistry , cell culture , phenanthroline , cytotoxic t cell , hep g2 , breast carcinoma , cancer research , biochemistry , cancer , breast cancer , metal , biology , medicine , crystallography , organic chemistry , colorectal cancer , chemotherapy , genetics , catalysis
Two new dinuclear Pt(II) complexes with different aromatic nitrogen‐containing heterocyclic compounds as the bridging ligands, [{Pt(en)Cl} 2 ( μ ‐1,7‐phen)](ClO 4 ) 2 ⋅H 2 O ( C1 ) and [{Pt(en)Cl} 2 ( μ ‐4,7‐phen)](ClO 4 ) 2 ⋅H 2 O ( C2 ), (1,7‐phen and 4,7‐phen are 1,7‐phenanthroline and 4,7‐phenanthroline while en is a bidentate coordinated ethylenediamine), were synthesized and structurally characterized by NMR ( 1 H and 13 C), IR and UV‐vis spectroscopy. In vitro cytotoxic activity of these complexes was evaluated against two tumor cell lines, human breast carcinoma (MDA‐MB‐231) and mouse breast carcinoma cells (4T1), and against one type of healthy human fibroblasts cells (MRC‐5). Platinum complex C1 showed stronger selectivity toward MDA‐MB‐231 and 4T1 breast carcinoma cells in comparison to cisplatin and oxaliplatin. Complex C2 displayed lower cytotoxicity than cisplatin and oxaliplatin in case of all stated cell lines, showing selectivity comparable to oxaliplatin.