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Fused Chromeno‐Thieno/Furo‐Pyridines as Potential Analogs of Lamellarin D and their Anticancer Activity Evaluation
Author(s) -
Kumar T. Uday,
Bobde Yamini,
Pulya Sravani,
Rangan Krishnan,
Ghosh Balaram,
Bhattacharya Anupam
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201902946
Subject(s) - furan , thiophene , pyridine , thio , stereochemistry , cancer cell lines , yield (engineering) , chemistry , molecule , combinatorial chemistry , medicinal chemistry , cancer , cancer cell , organic chemistry , materials science , biology , metallurgy , genetics
A linear route for the preparation of chromeno‐thio/furo‐pyridine system as potential analogs for anticancer compound lamellarin D is reported in this paper. The target molecules were obtained in modest to good yields by using FeCl 3 catalyzed modified Pictet‐Spengler reaction as the crucial final step. Compounds bearing furan rings showed higher overall yield compared to their thiophene congeners. Final molecules were subjected to anticancer activity screening against three different cancer cell lines. Compounds bearing fused furan rings showed better activity, with the best IC 50 value (6.83 μM) obtained when 4‐(4‐methoxyphenyl)‐6 H ‐chromeno[3,4‐ b ]furo[3,2‐ d ]pyridin‐6‐one was screened against MCF‐7 (breast cancer) cell lines.